GSK3787
Data Sheet
For research use only. Not for human use.
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| CAS No. | 188591-46-0 | Cat. No. | BCP07113 |
| Name | GSK3787 | ||
| Synonyms | GSK 3787; GSK-3787; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C15H12ClF3N2O3S | M. Wt | 392.78 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK3787 is potent and selective PPAR beta/delta (Peroxisome Proliferator-Activated Receptor) antagonist (IC50 in PPAR ligand displacement assays = 200 nM against human PPARβ and >10 μM against PPARα or PPARγ). GSK3787 acts by covalently modifying Cys249 within the ligand binding pocket, and has been shown to antagonize the induction of PPARδ-regulated target genes in skeletal muscle cells. | ||
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