Sarpogrelate hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 135159-51-2 | Cat. No. | BCP07360 |
| Related Products | 125926-17-2（Sarpogrelate） | ||
| Name | Sarpogrelate hydrochloride | ||
| Synonyms | MCI-9042; MCI9042; MCI 9042; LS-187,118; LS187,118; LS 187,118; Sarpogrelate HCl; | ||
| SMILES | O=C(O)CCC(OC(COC1=CC=CC=C1CCC2=CC=CC(OC)=C2)CN(C)C)=O.[H]Cl | ||
| Chemical Name | |||
| Formula | C24H32ClNO6 | M. Wt | 465.97 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sarpogrelate is a drug which acts as an antagonist at the 5HT2A and 5-HT2B receptors. Sarpogrelate was shown to have the same affinity as ritanserin for 5-HT2A receptors, with a Ki value of 8.39 nM . Sarpogrelate lacked prominent 5-HT1-like, 5-HT3, beta, H1, H2 and M3 antagonist activity and weakly blocked alpha 1-adrenoceptors (pKB = 6.30). (S)-M-1 showed weak affinity for 5-HT1-like receptors (pKB = 6.30), alpha 1- (pKB = 6.80) and beta- (pKB = 6.54) adrenoceptors, while (R)-M-1 was a weak antagonist at histamine H1 receptors (pKB = 6.49) [2]. After 12 weeks of sarpogrelate administration, FBF and LBF responses during RH showed significant increases from 13.2 +/- 1.7 to 18.1 +/- 2.2 mL/min per 100 mL tissue (P < 0.01) and from 8.2 +/- 0.9 to 14.2 +/- 2.1 mL/min per 100 mL tissue (P < 0.05), respectively. | ||
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