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Nebivolol Chemical Structure

Nebivolol

Data Sheet For research use only. Not for human use.
Cat. No. :BCP07579CAS No. :118457-14-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 118457-14-0 Cat. No. BCP07579
Name Nebivolol
Synonyms Nebilet;Bystolic;R 065824;
SMILES
Chemical Name
Formula C22H25F2NO4 M. Wt 405.43
Purity 98% Storage Store at 4-8°C
Description Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM. Target: β1- adrenergic receptor Nebivolol reduces cell proliferation of human coronary smooth muscle cells (haCSMCs) and endothelial cells (haECs) in a concentration- and time-dependent maner. Nebivolol treatment for 7 days causes significant reduction in cell growth of haCSMCs with IC50 of 6.1 μM, and inhibits accelerated haCSMC proliferation stimulated by growth factors PDGF-BB, bFGF, and TGFβ with IC50 values of 6
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