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PP2 Chemical Structure

PP2

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP07605CAS No. ：172889-27-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 172889-27-9 Cat. No. BCP07605
Name PP2
Synonyms AG 1879; AG-1879; AG1879; PP 2; PP-2;Src family kinase inhibitor PP2;
SMILES
Chemical Name
Formula C15H16ClN5 M. Wt 301.77
Purity 98% Storage Store at 4-8°C
Description PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). PP2 does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 ?M), or ZAP-70 (IC50 > 100 ?M). PP2 inhibits the activation of focal adhesion kinase as well as its phosphorylation at Tyr577. PP2 also inhibits anti-CD3-stimulated tyrosine phosphorylati
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H-NMR HPLC
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