Encorafenib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP08458CAS No. ：1269440-17-6Purity：98%

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CAS No.	1269440-17-6	Cat. No.	BCP08458
Name	Encorafenib
Synonyms	LGX-818; LG X818;LGX818;
SMILES	CC(C)N1C=C(C(=N1)C2=C(C(=CC(=C2)Cl)NS(=O)(=O)C)F)C3=NC(=NC=C3)NCC(C)NC(=O)OC
Chemical Name
Formula	C22H27ClFN7O4S	M. Wt	540.01
Purity	98%	Storage	Store at 4-8°C
Description	Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival.