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SSR128129E Chemical Structure

SSR128129E

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP08581CAS No. ：848318-25-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 848318-25-2 Cat. No. BCP08581
Name SSR128129E
Synonyms SSR 128129E;SSR-128129E;SSR-128129-E;
SMILES
Chemical Name
Formula C18H15N2NaO4 M. Wt 346.31
Purity 98% Storage Store at 4-8°C
Description SSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. SSR128129E exhibits allosteric properties, including probe dependence, signaling bias, and ceiling effects. Inhibition by SSR128129E is highly conserved throughout the animal kingdom. Oral delivery of SSR128129E inhibits arthritis and tumors that are relatively refractory to anti-vascular endothelial growth factor receptor-2 antibodies. Thus, orally-active extracellularly acting small-molecule modulators of RTKs with allosteric properties can be developed and may offer opportunities to improve anticancer treatment.
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