MK-8745

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP09365CAS No. ：885325-71-3Purity：98%

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CAS No.	885325-71-3	Cat. No.	BCP09365
Name	MK-8745
Synonyms	MK 8745;MK8745;885327-89-9;
SMILES
Chemical Name
Formula	C20H19ClFN5OS	M. Wt	431.91
Purity	98%	Storage	Store at 4-8°C
Description	MK-8745 leads to cell cycle arrest at the G2/M phase with accumulation of tetraploid nuclei followed by cell death in non-Hodgkin lymphoma (NHL) cell lines. Treatment with MK-8745 induces p21(waf1/cip1) and CycB1, indicating cell cycle arrest and an increase in the G2/M phase cell population. Following MK-8745 treatment, Aurora-A substrates (TACC3, Eg5 and TPX2) are rapidly degraded following the reduction of phospho-Aurora-A. MK8745 induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK8745 results in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. p53-dependent apoptosis by MK8745 is further confirmed in HCT 116 p53(-/-) cells transfected with wild-type p53.