Products

Cas No.Product NameDescription
220127-57-1Imatinib mesylateImatinib mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia .
879085-55-9Vismodegib Vismodegib is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
1089283-49-7GSK1904529AGSK1904529A, which potently inhibits IGF-IR (IC50= 27 nmol/L) and IR (IC50= 25 nmol/L) activities in vitro and in vivo, is a promising candidate for therapeutic use in solid and hematologic cancers.
929095-18-1GSK461364GSK461364 is a potent small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki of 2.2 nM.
852808-04-9ABT-737ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts.
796967-16-3LinifanibLinifanib (ABT-869) is a structurally novel, potent RTK and VEGF and PDGF receptor families inhibitor with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively.
379231-04-6AZD0530Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.
414864-00-9/866323-14-0BelinostatBelinostat also known as PXD101 is a HDAC inhibitor with IC50 of 27 nM.
755038-02-9BI 2536BI 2536 is Plk1 inhibitor with an IC50 of 0.83 nM.
775304-57-9TranslarnaPTC124 is CFTR-G542X nonsense allele inhibitor.
871038-72-1Raltegravir potassiumRaltegravir Potassium Salt is a potent human immunodeficiency virus (HIV) integrase inhibitor
162635-04-3TemsirolimusTemsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay.
1146699-66-2BMS-708163BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM).
58880-19-6Trichostatin ATrichostatin A is a selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM).
873837-23-1BMS-599626 HClBMS-599626 (BMS-599626; AC480) is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively.
380843-75-4BosutinibBosutinib is Src family kinase inhibitor.
697761-98-1ElvitegravirElvitegravir is a human immunodeficiency virus integrase inhibitor with EC50 of 0.7, 2.8 and 1.4 for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD.
159351-69-6EverolimusEverolimus (RAD001) also known as SDZ-RAD, Certican, Zortress, Afinitorm is MTOR inhibitor with IC50 of 0.63 nM.
726169-73-9MocetinostatMGCD0103 (Mocetinostat) is a potent HDAC inhibitor with IC50 of 0.15, 0.29 and 1.66 μM for HDAC 1, HDAC 2 and HDAC 3, respectively.
404950-80-7Panobinostat Panobinostat is a HDAC inhibitor. IC50 for inhibition of proliferation in MOLT-4 cells is approximately 5 μM and for Reh cells is approximately 20 μM.

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PI3K/Akt/mTOR
Cell Cycle/Checkpoint
Angiogenesis/Tyrosine Kinase
Apoptosis Pathway
PARP/BET
Aurora/Ksp Pathway
MAPK Pathway
Hormone Pathay
Integrase/CCR5
Proteases/HSP90/HSP70 Pathway
Wnt/Hedgehog/Notch Pathway
Jak/Stat Pathway
Ca/cAMP/Lipid Signaling Pathway
Neuro Signaling Pathway
TGF-beta/Smad Signaling Pathway
GPCR Pathway
Ion channel Pathway
Cytochrome P450 Pathway
Others Pathway
Intermediate