Roquinimex
| CAS No. | 84088-42-6 | Cat. No. | BCP29884 |
| Name | Roquinimex | ||
| Synonyms | Linomide; FCF89; FCF-89; FCF 89; LS-2616; LS2616; LS 2616; ABR212616; PNU212616; ABR-212616; PNU-212616; ABR 212616; PNU 212616; | ||
| Formula | C18H16N2O3 | M. Wt | 308.33 |
| Description | Roquinimex is a quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | TNF Receptor | ||
Structure
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