Rp-8-bromo-Cyclic AMPS sodium salt
| CAS No. | 925456-59-3 | Cat. No. | BCP29965 |
| Name | Rp-8-bromo-Cyclic AMPS sodium salt | ||
| Synonyms | Rp-8-bromo-Cyclic AMPS sodium ;Rp-8-Br-cAMPS;Rp-8-bromo-cAMPS;8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer; | ||
| Formula | C10H10BrN5NaO5PS | M. Wt | 446.15 |
| Description | Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart. | ||
| Pathways | GPCR/G Protein Wnt/Stem Cell | ||
| Targets | PKA | ||
Structure
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