Golimumab
| CAS No. | 476181-74-5 | Cat. No. | BCP30499 |
| Name | Golimumab | ||
| Synonyms | Simponi;CNTO 148;CNTO-148;CNTO148; | ||
| Formula | C6530H10068N1752O2026S44 | M. Wt | 147 kg/mol |
| Description | Golimumab (CNTO 148) is a human monoclonal antibody which is used as an immunosuppressive drug. Golimumab targets tumor necrosis factor alpha (TNF-alpha), a pro-inflammatory molecule and hence is a TNF inhibitor. Profound reduction in C-reactive protein (CRP) levels, interleukin (IL)-6, intercellaular adhesion molecules (ICAM)-1, matrix metalloproteinase (MMP)-3, and vascular endothelial growth factor (VEGF) demonstrates golimumab as an effective modulator of inflammatory markers and bone metabolism. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | TNF Receptor | ||
Structure
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