MSC1094308
| CAS No. | 2219320-08-6 | Cat. No. | BCP31488 |
| Name | MSC1094308 | ||
| Synonyms | MSC-1094308; MSC 1094308; | ||
| Formula | C29H29F3N2 | M. Wt | 462.55 |
| Description | MSC1094308 is a Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. MSC1094308 binds to a previously characterized drugable hotspot of p97, thereby inhibiting the D2 ATPase activity. Our results furthermore indicate that a similar allosteric site exists in VPS4B, suggesting conserved allosteric circuits and drugable sites in both type I and II AAA ATPases. Our results may thus guide future chemical tool and drug discovery efforts for the biomedically relevant AAA ATPases. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | p97 | ||
Structure
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