GNF4877
| CAS No. | 2041073-22-5 | Cat. No. | BCP31624 |
| Name | GNF4877 | ||
| Synonyms | GNF 4877;GNF-4877; | ||
| Formula | C25H27FN6O4 | M. Wt | 494.52 |
| Description | GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells). | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase PI3K/Akt/mTOR Wnt/Stem Cell | ||
| Targets | DYRK GSK3 | ||
Structure
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