Deschloroclozapine
| CAS No. | 1977-07-7 | Cat. No. | BCP46891 |
| Name | Deschloroclozapine | ||
| Synonyms | DCZ;Dopamine serotonin antagonist-1; | ||
| Formula | C18H20N4 | M. Wt | 292.38 |
| Description | Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs. It is a derivative of clozapine, and exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N-oxide, and 50-fold greater affinity compared to DREADD agonist 21. Deschloroclozapine displays low 'off-target' receptor binding and rapid binding and activation of hM3Dq and hM4Di in mice and non-human primates. It also induces spatial memory deficits in non-human primates expressing hM4Di in the prefrontal cortex. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | mAChR | ||
Structure
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