SP-146
| CAS No. | 2682114-54-9 | Cat. No. | BCP48903 |
| Name | SP-146 | ||
| Synonyms | SP 146;SP146; | ||
| Formula | C25H20FN7O | M. Wt | 453.47 |
| Description | SP-96 is a highly potent, selective and non-ATP-competitive Aurora B (IC50=0.316 nM) inhibitor and shows >2000 fold selectivity against FLT3 and KIT. SP-96 shows selective growth inhibition in NCI60 screening, incluing MDA-MD-468 (GI50=107 nM). SP-96 can be used for the research of triple negative breast cancer (TNBC). | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | Aurora | ||
Structure
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