(S)-(-)-PH-797804
| CAS No. | 1358027-80-1 | Cat. No. | BCP49370 |
| Name | (S)-(-)-PH-797804 | ||
| Synonyms | PH 797804;PH-797804;PH797804; | ||
| Formula | C22H19BrF2N2O3 | M. Wt | 477.3 |
| Description | PH 797804 is a potent and selective p38α/β inhibitor (IC50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active. | ||
| Pathways | MAPK Pathway | ||
| Targets | p38 MAPK | ||
Structure
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