Encorafenib
| CAS No. | 1269440-17-6 | Cat. No. | BCP08458 |
| Name | Encorafenib | ||
| Synonyms | LGX-818; LG X818;LGX818; | ||
| Formula | C22H27ClFN7O4S | M. Wt | 540.01 |
| Description | Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. | ||
| Pathways | MAPK Pathway | ||
| Targets | Raf | ||
Structure
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