TAK-632
| CAS No. | 1228591-30-7 | Cat. No. | BCP08426 |
| Name | TAK-632 | ||
| Synonyms | TAK 632; TAK 632; | ||
| Formula | C27H18F4N4O3S | M. Wt | 554.52 |
| Description | TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio. In addition, TAK-632 was shown preclinically to be a selective kinase inhibitor targeting pan-RAF kinase activity by testing against a panel of kinases. In both A375 (BRAFV600E) and HMVII (NRASQ61K) xenograft models in rats, TAK-632 demonstrated regressive antitumor efficacy by twice daily, 14-day repetitive administration without significant body weight loss | ||
| Pathways | Cell Cycle/DNA Damage MAPK Pathway Epigenetics | ||
| Targets | Aurora Raf | ||
Structure
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