XL019
| CAS No. | 945755-56-6 | Cat. No. | BCP07987 |
| Name | XL019 | ||
| Synonyms | XL-019; XL 019; | ||
| Formula | C25H28N6O2 | M. Wt | 444.53 |
| Description | XL019 is a potent and selective JAK2 inhibitor. XL019 shows good biochemical and cellular potency against JAK2 with good selectivity against the Janus Kinase family as well as a broad kinase panel. XL019 was selected as a clinical candidate and advanced into human clinical trials where it was evaluated in patients with primary myelofibrosis, post-polycythemia vera, or post-essential thrombocythemia myelofibrosis. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell Epigenetics | ||
| Targets | JAK | ||
Structure
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