PP2

CAS No.	172889-27-9	Cat. No.	BCP07605
Name	PP2
Synonyms	AG 1879; AG-1879; AG1879; PP 2; PP-2;Src family kinase inhibitor PP2;
Formula	C15H16ClN5	M. Wt	301.77

Description	PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). PP2 does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 ?M), or ZAP-70 (IC50 > 100 ?M). PP2 inhibits the activation of focal adhesion kinase as well as its phosphorylation at Tyr577. PP2 also inhibits anti-CD3-stimulated tyrosine phosphorylati
Pathways	Angiogenesis/Protein Tyrosine Kinase
Targets	Src/Bcr Abl

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