Binimetinib

CAS No.	606143-89-9	Cat. No.	BCP06780
Name	Binimetinib
Synonyms	ARRY-162; ARRY-438162; MEK 162; ARRY 162; ARRY 438162; ARRY438162;ARRY 438162; ARRY-438162; MEK162;
Formula	C17H15BrF2N4O3	M. Wt	441.23

Description	Binimetinib(ARRY-162; MEK162) is an orally available inhibitor of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2) with potential antineoplastic activity. Binimetinib, noncompetitive with ATP, binds to and inhibits the activity of MEK1/2. Inhibition of MEK1/2 prevents the activation of MEK1/2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling. This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor. MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
Pathways	MAPK Pathway
Targets	MEK/ERK

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