Denibulin
| CAS No. | 284019-34-7 | Cat. No. | BCP21548 |
| Name | Denibulin | ||
| Synonyms | MN029; MN-029; MN 029; | ||
| Formula | C18H19N5O3S | M. Wt | 385.44 |
| Description | Denibulin is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Microtubule | ||
Structure
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