E7050
| CAS No. | 928037-13-2 | Cat. No. | BCP06122 |
| Name | E7050 | ||
| Synonyms | Golvatinib;E-7050;E 7050; | ||
| Formula | C33H37F2N7O4 | M. Wt | 633.69 |
| Description | Golvatinib, also known as E7050, is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth, migration and angiogenesis. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | c Met VEGFR | ||
Structure
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