(Z)-SMI-4a
| CAS No. | 438190-29-5 | Cat. No. | BCP06044 |
| Name | (Z)-SMI-4a | ||
| Synonyms | 327033-36-3;SMI-4a; SMI4a; SMI 4a; TCS PIM-1 4a; | ||
| Formula | C11H6F3NO2S | M. Wt | 273.23 |
| Description | SMI-4a is a potent and selective Pim protein kinase inhibitor, which blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. SMI-4a was found to induce phosphorylation of extracellular signal-related kinase1/2 (ERK1/2), and the combination of SMI-4a and a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor was highly synergistic in killing pre-T-LBL cells. SMI-4a may be developed as a therapeutic strategy for the treatment of pre-T-LBL. | ||
| Pathways | Jak/Stat Pathway | ||
| Targets | Pim | ||
Structure
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