Cobimetinib
| CAS No. | 934660-93-2 | Cat. No. | BCP05208 |
| Name | Cobimetinib | ||
| Synonyms | GDC-0973;XL-518;GDC 0973;XL 518;GDC0973;XL518; | ||
| Formula | C21H21F3IN3O2 | M. Wt | 531.31 |
| Description | in vitro: The combination of GDC-0973 with the PI3K inhibitor GDC-0941 resulted in combination efficacy in vitro and in vivo via induction of biomarkers associated with apoptosis, including Bcl-2 family proapoptotic regulators . in vivo: The population rate constants associated with tumor growth inhibition for GDC-0973 and GDC-0941 were 0.00102 and 0000651 μM(-1) h(-1), respectively. Using the model based on single-agent and QD combination efficacy data, simulations adequately described the tumor growth from the Q3D combination regimen . Following single doses of GDC-0973, estimated in vivo IC(50) values of %pERK decrease based on tumor concentrations in xenograft mice were 0.78 (WM-266-4) and 0.52 μmol/L (A375). | ||
| Related Products | 1369665-02-0（Cobimetinib hemifumarate） | ||
| Pathways | MAPK Pathway | ||
| Targets | MEK/ERK | ||
Structure
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