Gemcitabine hydrochloride
| CAS No. | 122111-03-9 | Cat. No. | BCP04160 |
| Name | Gemcitabine hydrochloride | ||
| Synonyms | Gemcitabine HCl; LY188011 hydrochloride;LY 188011 hydrochloride;LY-188011 hydrochloride; | ||
| Formula | C9H12ClF2N3O4 | M. Wt | 299.66 |
| Description | Gemcitabine induced NF-κB activity in BxPC-3, PANC-1, and MIA PaCa-2 cells and decreased the level of the NF-κB inhibitor IκBα in BxPC-3 and PANC-1 cells. Treatment of BxPC-3 cells with low dose Gemcitabine for 48 hours results in a dose-dependent increase in NF-κB binding. In contrast, NF-κB DNA binding is decreased in BxPC-3 cells treated with the higher Gemcitabine doses for 48 h; however, 24-h treatment with these higher doses increases NF-κB binding in BxPC-3 cells. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis Antimetabolite | ||
Structure
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