Actinomycin D

Chemical Properties

CAS No.	50-76-0	Cat. No.	BCP04082
Name	Actinomycin D
Synonyms
Formula	C62H86N12O16	M. Wt	1255.44

Biological Activity

Description	Actinomycin D showed a concentration-dependent decrease of DNA repair activity with the IC50 of 0.42 μM. Actinomycin D (dactinomycin), a member of actinomycines, which are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces. Have been used for many years as an older chemotherapy, actinomycin D binds to double- and single-stranded DNA to inhibit DNA and RNA synthesis by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase.

Description

Actinomycin D showed a concentration-dependent decrease of DNA repair activity with the IC50 of 0.42 μM. Actinomycin D (dactinomycin), a member of actinomycines, which are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces. Have been used for many years as an older chemotherapy, actinomycin D binds to double- and single-stranded DNA to inhibit DNA and RNA synthesis by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase.

Structure

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