SB415286
| CAS No. | 264218-23-7 | Cat. No. | BCP02901 |
| Name | SB415286 | ||
| Synonyms | SB-415286; SB 415286; | ||
| Formula | C16H10ClN3O5 | M. Wt | 359.72 |
| Description | Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis, and inflammation. SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. As a result of GSK3 inhibition, SB 415286 stimulates glycogen synthesis in the Chang human liver cell line with an EC50 value of 2.9 μM. SB 415286 also protects primary neurons from death induced by the PI3-kinase pathway. | ||
| Pathways | Wnt/Stem Cell PI3K/Akt/mTOR | ||
| Targets | GSK3 | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.