GSK1904529A
| CAS No. | 1089283-49-7 | Cat. No. | BCP01719 |
| Name | GSK1904529A | ||
| Synonyms | GSK 1904529A;GSK-1904529A;GSK 4529; | ||
| Formula | C44H47F2N9O5S | M. Wt | 851.96 |
| Description | GSK1904529A is a reversible, ATP-competitive inhibitor and has enzyme-inhibitor binding values against IGF-1R and IR with Ki of 1.6 nM and 1.3 nM, respectively. GSK1904529A potently inhibits the ligand-induced phosphorylation of IGF-1R and IR at concentrations above 0.01 μM, followed by blocking downstream signaling (AKT, IRS-1, and ERK). GSK1904529A potently inhibits NIH-3T3/LISN, TC-71, SK-N-MC, SK-ES RD-ES cells with IC50 of 60 nM, 35 nM, 43 nM, 61 nM and 62 nM, respectively. GSK1904529A also | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | IGF1R | ||
Structure
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