CYC-116
| CAS No. | 693228-63-6 | Cat. No. | BCP01887 |
| Name | CYC-116 | ||
| Synonyms | CYC116;CYC 116; | ||
| Formula | C18H20N6OS | M. Wt | 368.46 |
| Description | The most Aurora-selective CYC116 shows inhibitory effect on Aurora A and B kinases 50-fold more potently than any of the CDKs assayed.CYC116 is initially screened against a panel of human leukemia and solid tumor cell lines using an MTT antiproliferative assay. The results show that CYC116 has broad-spectrum antitumor activity and shows specific cytotoxicity against the acute myelogenous leukemia cell line MV4-11 with IC50 of 34 nM.In addition, anti-proliferative activity of CYC116 is found to be associated with Aurora A and B modulation such as, inhibition of Aurora autophosphorylation, reduction of histone H3 phosphorylation, polyploidy, followed by cell death, resulting from a failure in cytokinesis. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | Aurora | ||
Structure
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