Tolrestat
| CAS No. | 82964-04-3 | Cat. No. | BCP02377 |
| Name | Tolrestat | ||
| Synonyms | Tolrestatin; AY-27773; AY 27773; AY27773;Alredase;Lorestat; | ||
| Formula | C16H14F3NO3S | M. Wt | 357.35 |
| Description | Tolrestat inhibited in dose-dependent fashion the AR from bovine lenses (IC50, 3.5 X 10(-8) mol/L) and the formation of sorbitol in human RBC incubated with glucose (IC50, 3 X 10(-8) mol/L). Upon administration with the diet to rats made galactosemic or diabetic, tolrestat decreased, in a dose-related fashion, the accumulation of galactitol or sorbitol in the sciatic nerve and lens. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Aldose Reductase | ||
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Aldo‐keto reductases‐mediated cytotoxicity of 2‐deoxyglucose: A novel anticancer mechanism
Publications Citing of Biochempartner's Tolrestat(CAS:82964-04-3) |
Structure
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