Canertinib dihydrochloride

  • Chemical Properties
CAS No. 289499-45-2 Cat. No. BCP01902
Name Canertinib dihydrochloride
Synonyms Canertinib 2HCl;CI-103;CI 103;CI103;
Formula C24H27Cl3FN5O3 M. Wt 558.86
  • Biological Activity
Description Canertinib Dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents.
Related Products 267243-28-7(Canertinib)
Pathways Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway 
Targets EGFR HER2 

Structure

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