YH239-EE
| CAS No. | 1364488-67-4 | Cat. No. | BCP09904 |
| Name | YH239-EE | ||
| Synonyms | YH239EE; | ||
| Formula | C25H27Cl2N3O4 | M. Wt | 504.41 |
| Description | YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). | ||
| Pathways | Apoptosis Pathway | ||
| Targets | Mdm2 p53 | ||
Structure
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