Loxistatin acid

  • Chemical Properties
CAS No. 76684-89-4 Cat. No. BCP12303
Name Loxistatin acid
Synonyms E-64-C;E-64 C;E-64C;E64C;EP 475;EP475;EP-475;
Formula C15H26N2O5 M. Wt 314.38
  • Biological Activity
Description Loxistatin Acid, a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.The compound has been demonstrated to form a complex with papain by binding via a thioether covalent bond. Studies indicate that E-64-c, also known as Ep-475, is a more potent inhibitor of cathepsins B and L compared to E-64. Mouse lymphosarcoma LS studies show that Ep-475 decreases the effects of cyclophosphamide.
Pathways Protease/Metabolic Enzyme 
Targets Cathepsin 

Structure

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