Tpl2 Kinase Inhibitor
| CAS No. | 871307-18-5 | Cat. No. | BCP16321 |
| Name | Tpl2 Kinase Inhibitor | ||
| Synonyms | TC-S 7006; TC S 7006; TCS 7006; Tpl2-IN-2p; | ||
| Formula | C21H14ClFN6 | M. Wt | 404.83 |
| Description | Tpl2 Kinase Inhibitor is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro. Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes. Cell permeable. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | TNF Receptor | ||
Structure
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