Ro 46-2005

  • Chemical Properties
CAS No. 150725-87-4 Cat. No. BCP17756
Name Ro 46-2005
Synonyms Ro 462005;Ro 46 2005;
Formula C23H27N3O6S M. Wt 473.54
  • Biological Activity
Description Ro 46-2005 proves to be equipotent (IC50 200-500 nM) for inhibition of [125I]ET-1 binding on the two known ET receptor subtypes (ETA and ETB). Ro 46-2005 also inhibits the functional consequences of ET-1 stimulation: the ET-l-induced release of arachidonic acid from rat mesangial cells was inhibited with an IC50 of 1.8 μM.
Pathways GPCR/G Protein 
Targets Endothelin Receptor 

Structure

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