BGP-15 dihydrochloride
| CAS No. | 66611-37-8 | Cat. No. | BCP24844 |
| Name | BGP-15 dihydrochloride | ||
| Synonyms | BGP15; BGP-15; BGP 15;BGP-15 2HCl; | ||
| Formula | C14H24Cl2N4O2 | M. Wt | 351.27 |
| Description | BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. BGP-15 also inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury. Moreover, BGP-15 was found to prevent imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | PARP | ||
Structure
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