Monastrol

  • Chemical Properties
CAS No. 254753-54-3 Cat. No. BCP19385
Name Monastrol
Synonyms
Formula C14H16N2O3S M. Wt 292.35
  • Biological Activity
Description Monastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint. Monastrol binds to the KSP-ADP complex, forming a KSP-ADP- monastrol ternary complex, which cannot bind to microtubules productively and cannot undergo further ATP-driven conformational changes.
Pathways Cell Cycle/DNA Damage 
Targets Kinesin 

Structure

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