Chk2 Inhibitor II

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP09077CAS No. ：516480-79-8Purity：98%

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Chemical Properties&Biological Activity

CAS No.	516480-79-8	Cat. No.	BCP09077
Name	Chk2 Inhibitor II
Synonyms	BML277; BML-277; BML 277;
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Chemical Name
Formula	C20H14ClN3O2	M. Wt	363.8
Purity	98%	Storage	Store at 4-8°C
Description	BML-277 (Chk2 Inhibitor II) is a Chk2 (checkpoint kinase 2) inhibitor. BML-277 protects T cells from apoptosis by controlling the response of p53 to radiation-induced DNA breaks. This is suggestive of BML-277's use as an adjuvant for radiation therapy in cancer. BML-277 is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. It has also been found to weakly inhibit 31 other kinases.

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Chk2 Inhibitor II

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