Ponesimod New
Data Sheet
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| CAS No. | 854107-55-4 | Cat. No. | BCP17902 |
| Name | Ponesimod | ||
| Synonyms | ACT-128800; | ||
| SMILES | CCCN=C1N(C(=O)C(=CC2=CC(=C(C=C2)OCC(CO)O)Cl)S1)C3=CC=CC=C3C | ||
| Chemical Name | |||
| Formula | C23H25ClN2O4S | M. Wt | 460.97 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Ponesimod, also known as ACT-128800, is a potent, and orally active selective S1P(1) agonist. Ponesimod activated S1P(1)-mediated signal transduction with high potency (EC(50) of 5.7 nM) and selectivity. Ponesimod prevented edema formation, inflammatory cell accumulation, and cytokine release in the skin of mice with delayed-type hypersensitivity. Ponesimod also prevented the increase in paw volume and joint inflammation in rats with adjuvant-induced arthritis. Ponesimod may represent a new therapeutic approach in lymphocyte-mediated autoimmune diseases. | ||
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