曲古菌素A
| CAS号 | 58880-19-6 | 货号 | BCP01776 |
| 中文名 | 曲古菌素A | ||
| 英文名 | Trichostatin A | ||
| 中文别名 | 曲古抑菌素A;曲古抑菌素;曲古柳菌素A; | ||
| 英文别名 | TSA; (+)-Trichostatin A; Trichostatin A (R-isomer); | ||
| 分子式 | C17H22N2O3 | 分子量 | 302.37 |
| 生物活性 | Trichostatin A, also known as TSA, is a HDAC inhibitor. TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. TSA inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM. | ||
| 信号通路 | Cell Cycle/DNA Damage Epigenetics | ||
| 靶 点 | HDAC | ||
结构式
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