Obatoclax
| CAS No. | 803712-67-6 | Cat. No. | BCP20625 |
| Name | Obatoclax | ||
| Synonyms | GX 015-070; GX015-070; GX-015-070; GX 015070; GX015070; GX-015070; GX 015-070; GX15-070; | ||
| Formula | C20H19N3O | M. Wt | 317.38 |
| Description | Obatoclax, also known as GX 015-070, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | Bcl2 | ||
Structure
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