Lavendustin A
| CAS No. | 125697-92-9 | Cat. No. | BCP20666 |
| Name | Lavendustin A | ||
| Synonyms | RG 14355; RG-14355; RG14355;LAVENDUSTIN A; | ||
| Formula | C21H19NO6 | M. Wt | 381.38 |
| Description | Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate.It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM).2 It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR | ||
Structure
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