NCT-503
| CAS No. | 1916571-90-8 | Cat. No. | BCP20674 |
| Name | NCT-503 | ||
| Synonyms | NCT 503; NCT503; | ||
| Formula | C20H23F3N4S | M. Wt | 408.48 |
| Description | NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 μM.It has been shown to reduce the production of glucose-derived serine in cells and to suppress the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors. | ||
| Pathways | Others Pathway | ||
| Targets | Others | ||
Structure
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