KW-2449 HCl

  • Chemical Properties
CAS No. 841259-17-4 Cat. No. BCP20681
Name KW-2449 HCl
Synonyms
Formula C20H21ClN4O M. Wt 368.86
  • Biological Activity
Description KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC(50) of 6.6nM, modestly potent to FGFR1, Bcr-Abl and Aurora A, little effect on PDGFRbeta, IGF-1R, EGFR.
Pathways Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage Epigenetics 
Targets Src/Bcr Abl Aurora FLT3 FGFR 

Structure

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