Lys05
| CAS No. | 1391426-24-6 | Cat. No. | BCP20708 |
| Name | Lys05 | ||
| Synonyms | Lys01 trihydrochloride;Lys-01 trihydrochloride;Lys 01 trihydrochloride;LYS05; LYS-05; | ||
| Formula | C23H26Cl5N5 | M. Wt | 549.75 |
| Description | Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Lys05 is therefore a new lysosomal autophagy inhibitor that has potential to be developed further into a drug for cancer and other medical applications. | ||
| Pathways | Others Pathway | ||
| Targets | Autophagy | ||
Structure
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