Rimiducid
| CAS No. | 195514-63-7 | Cat. No. | BCP20825 |
| Name | Rimiducid | ||
| Synonyms | AP1903;AP 1903;AP-1903; | ||
| Formula | C78H98N4O20 | M. Wt | 1411.63 |
| Description | AP1903, also known as Rimiducid, is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. This agent is used to homodimerize the Fv-containing drug-binding domains of genetically engineered receptors such as the iCD40 receptor of the autologous dendritic cell vaccine BP-GMAX-CD1, resulting in receptor activation. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | TNF Receptor | ||
Structure
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