CPI-455
| CAS No. | 1628208-23-0 | Cat. No. | BCP20722 |
| Name | CPI-455 | ||
| Synonyms | CPI 455;CPI455; | ||
| Formula | C16H15ClN4O | M. Wt | 314.77 |
| Description | CPI-455 is an inhibitor of the lysine demethylase 5 family (KDM5A-D). CPI-455 binds to the demethylase active site and selectively inhibits KDM5A-D (IC50s = 2-10 nM) over KDM2-4, 6, and 7 family members (IC50s = 1 to >25 μM). It increases histone H3K4me2/3 methylation in vitro and decreases the number of drug-tolerant cells in PC9 non-small cell lung, M14 melanoma, and SKBR3 breast cancer cell populations. CPI-455 also reduces growth of glioblastoma cells resistant to temozolomide in a dose-dependent manner. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Demethylase | ||
Structure
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