Rifabutin
| CAS No. | 72559-06-9 | Cat. No. | BCP20425 |
| Name | Rifabutin | ||
| Synonyms | Ansamycin; LM-427; LM 427; LM427; | ||
| Formula | C46H62N4O11 | M. Wt | 847 |
| Description | IC50 Value: Target: Antibacterial Rifabutin is primarily bactericidal antibiotic drug used to treat tuberculosis. Its effect on bacteria is based on the DNA-dependent RNA polymerase blocking drug rifamycin S., a semi-synthetic derivative. It is effective, for example, in highly resistant mycobacteria, Gram-positive bacteria (and some are effective against Gram-negative bacteria), but also against Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare. Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Antibiotic | ||
Structure
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