ZK-756326
| CAS号 | 874911-96-3 | 货号 | BCP20725 |
| 中文名 | ZK-756326 | ||
| 英文名 | ZK-756326 | ||
| 中文别名 | |||
| 英文别名 | ZK 756326;ZK756326; | ||
| 分子式 | C21H28N2O3 | 分子量 | 356.47 |
| 生物活性 | ZK 756326 is a selective, non-peptide CKR-8 (CCR8 chemokine receptor) agonist (IC50 values are 1.8 and 2.6μM for human and mouse receptors respectively). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion. ZK 756326 displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs.Selective, non-peptide CCR8 chemokine receptor agonist (IC50 values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | CCR | ||
结构式
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